Mary M.Y. WAYE

Research Professor


Qualifications BSc (Bacteriology & Immunology, U. Western Ontario, Canada), PhD (Medical Biophysics, U. Toronto, Canada)
Tel (852) 3943 9302
Email mary-waye@cuhk.edu.hk
Research Expertise Study of association of genetic variants with human conditions, including psychiatric disorders.
Human genetic study of developmental dyslexia. Studies on twins and language development. Molecular characterization of gene functions using multidisciplinary approaches.
Researcher ID A-9674-2008
ORCID 0000-0002-2582-4917
Scopus ID 7006687733

Biography

Dr. Waye received the degree of Bachelor of Science (Hon) from the University of Western Ontario, Canada, majoring in Bacteriology and Immunology, and then took graduate work and received Ph.D. in Medical Biophysics at the University of Toronto, Canada. During her graduate period, she received support as a research student of the National Cancer Institute. In completing her Ph.D. she received a King George V Fellowship and received her post-doctoral training at the Laboratory of Molecular Biology, Medical Research Council, Cambridge, UK as a National Cancer Institute Research Fellow. She did research in the Division of Protein and Nucleic Acid and later also received training in the Division of Structural Studies in Cambridge. She returned to the University of Toronto as an assistant professor. She has been at The Chinese University of Hong Kong since 1992. She was appointed as the Founding Director of the Croucher Laboratory for Human Genomics in 2004.

Awards, Honours, and Achievements

Research Awards

  • Silver Poster Award at Global Proteome Research Congress, Human Proteome Organization (2004)

Honours

  • King George V Fellowship
  • Top applicant of National Cancer Institute of Canada Research Fellow (1982)
  • NCI Post-doctoral Fellowship, National Cancer Institute of Canada (1982 – 1985)
  • A publication ranked third in LetPub’s in citation ranking for 2015 Medical articles published by Chinese authors (2015年醫學領域中國作者發表的高被引研究論文排行榜排名第三) :
    Liang, W. C., Fu, W. M., Wong, C. W., Wang, Y., Wang, W. M., Hu, G. X., … Waye, M. M. Y. (2015). The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer. ONCOTARGET, 6(26), 22513-22525.
Grants

(in the capacity of Principal Investigator or Co-Investigator)

Funding BodyProject Title
Health Care and Promotion Scheme New wine in old bottle: the effects of Sudoku Mind Activation and Revitalizing Training (SMART) program on cognitive function among people with mild cognitive impairment
Food and Health Bureau - Health and Medical Research FundGenetic study of the SNARE gene family in Hong Kong Chinese with bipolar disorder
The Nethersole School of Nursing, CUHKDiscovery of predictive biomarkers of tamoxifen side effects and adherence based on genetic polymorphisms during adjuvant tamoxifen therapy in breast cancer patients in Hong Kong: a feasibility study
Food and Health Bureau - Health and Medical Research FundAssociation study of susceptibility genes in Wnt signaling pathway with attempted suicide
CUHK International Partnerships Development ProgrammeVisit René S. Kahn, MD PhD/Prof. Dr./Chief, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands
Research Committee Group Research SchemeReading Development in Chinese and in English: Genetic and Neuroscience Correlates
Research Grants Council - Collaborative Research FundReading Development in Chinese and in English: Genetic and Neuroscience Correlates
Collaborative Research FundReading development in Chinese and English: Genetic and Neuroscience correlates
Research Grants Council - General Research FundIntegrating spatio-temporal analysis and molecular epidemiology to study the transmission of tuberculosis in China
Food and Health Bureau - Health and Medical Research FundThe combination use of cardiovascular drugs with Danshen Gegen Decoction on hypertension hyperlipidemia and atherosclerosis
Research Fund for the Control of Infectious DiseasesPrevalence Of Human Adenovirus-36 (Ad-36) Infection In Hong Kong
National Natural Science Foundation of China亞洲人群的新基因和剪接外顯子的發現
Shenzhen Start up FundsFunctional Genomics and Biostatistical Computing Laboratory (MD12900)
Research Grants CouncilGenetic and Environmental influences on language and literacy development
Research Grants CouncilInteraction of TRPC channels with large conductance Ca2+-sensitive potassium channels in vascular smooth muscle cells
Germany/Hong Kong Joint Research SchemeCharacterization of Proteins Interacting with Rrad (ras-related associated with diabetes)
Medicine Panel Direct Grant, CUHKTo study the mechanism of action of the RhoC in metastasis of liver cancer cells
Research Grants CouncilIs Clinical Translation of Pharmacogenetics Possible in Anticoagulation Therapy?
Research Grants CouncilPharmacogenetics of HMG Co-A Reductase Inhibitors in Chinese Patients with Hyperlipidaemia: a Combined Pharmacodynamic-pharmacokinetic Approach
Croucher FoundationStrategic research area on “Viral, Hepatocarcinoma and Cardiomyopathy Genes”
Research Grants CouncilEstablishment of a SARS Coronavirus protein/peptide library and an antibody library as common platforms for biological and medical applications
Research Grants CouncilA Haplotype Map (HapMap) of the Human genome- Hong Kong Contribution

Selected Publications

Publication
Rao, S., Han, X., Shi, M., Siu, C. O., Waye, M. M. Y. , Liu, G., Wing, Y. K. (2019) Associations of the serotonin transporter promoter polymorphism (5-HTTLPR) with bipolar disorder and treatment response: A systematic review and meta-analysis. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 89, 214-226. doi: 10.1016/j.pnpbp.2018.08.035.
Liang, W. C., Wong, C. W., Liang, P. P., Shi, M., Cao, Y., Shitao, R., Kwok, S. W. T., Waye, M. M. Y. , Zhang, Q., Fu, W. M., Zhang, J. F. (2019). Translation of the circular RNA circβ-catenin promotes liver cancer cell growth through activation of the Wnt pathway. Genome Biology, 20, 84-95. doi: 10.1186/s13059-019-1685-4.
Rao, S., Han, X., Shi, M., Siu, C. O., Waye, M. M. Y. , Liu, G., Wing, Y. K. (2019). Associations of the serotonin transporter promoter polymorphism (5-HTTLPR) with bipolar disorder and treatment response: A systematic review and meta-analysis. Progress in Neuro-psychopharmacology and Biological Psychiatry, 89, 214-226. doi: 10.1016/j.pnpbp.2018.08.035.
Rao, S., Shi, M., Han, X., Lam, M. H. B., Liu, G., Wing, Y. K., So, H. C., Waye, M. M. Y. (2019). Genome-wide copy number variation-, validation- and screening study implicates a novel copy number polymorphism associated with suicide attempts in major depressive disorder. BioRxiv, doi: https://doi.org/10.1101/534909.
Rao, S., Siu, C. O., Shi, M., Zhang, J., Lam, M. H. B., Yu, M., Wing, Y. K., Waye, M. M. Y. (2018). Associations of Homer Scaffolding Protein 1 gene and psychological correlates with suicide attempts in Chinese: A pilot study of multifactorial risk model. Gene, 679, 382-388. doi: 10.1016/j.gene.2018.09.025.
Ge, E., Li, D., Luo, M., Tsui, K. W. S., Waye, M. M. Y. , Shen, X., Wei, X. (2018). Transmission of multidrug-resistant tuberculosis in Shanghai: roles of residential status. The International Journal of Tuberculosis and Lung Disease, 22 (12), 1462-1468. doi: 10.5588/ijtld.18.0125.
Tong, X., McBride, C., Ho, C. S. H., Waye, M. M. Y. , Chung, K. K., H., Wong, S. W. L., Chow, B. W. Y. (2018). Within- and cross-language contributions of morphological awareness to word reading and vocabulary in Chinese–English bilingual learners. Reading and Writing, 31(8), 1765–1786. doi: 10.1007/s11145-017-9812-7.
Lo, J. C. M., Ye, Y., Tong, X., McBride, C., Ho, C. S. H., Waye, M. M. Y. (2018). Delayed copying is uniquely related to dictation in bilingual Cantonese–English-speaking children in Hong Kong. Writing Systems Research, doi: 10.1080/17586801.2018.1481902.
Wang, Y., Wong, C. W., Yan, M., Li, L., Liu, T., Or, P. M., Tsui, S. K., Waye, M. M., Chan, A. M. (2018). Differential regulation of the pro-inflammatory biomarker, YKL-40/CHI3L1, by PTEN/Phosphoinositide 3-kinase and JAK2/STAT3 pathways in glioblastoma. Cancer Letters, 429, 54-65.
Liang WC, Ren JL, Wong CW, Chan SO, Waye MM, Fu WM, Zhang JF. (2018) LncRNA-NEF antagonized epithelial to mesenchymal transition and cancer metastasis via cis-regulating FOXA2 and inactivating Wnt/β-catenin signaling. Oncogene,37(11), 1445-1456. doi: 10.1038/s41388-017-0041-y. Epub 2018 Jan 9.
Law, B. M. H., Waye, M. M. Y. , So, W. K. W., Chair, S. Y. (2017). Hypotheses on the Potential of Rice Bran Intake to Prevent Gastrointestinal Cancer through the Modulation of Oxidative Stress. International Journal of Molecular Sciences, 18 (7), pii: E1352. doi: 10.3390/ijms18071352.
Chan CWH, Law BMH, So WKW, Chow KM, Waye MMY. (2017) Novel Strategies on Personalized Medicine for Breast Cancer Treatment: An Update. International Journal of Molecular Sciences, 18(11). pii: E2423. doi: 10.3390/ijms18112423. Review.
Waye MMY, Poo LK, Ho CS. (2017) Study of Genetic Association With DCDC2 and Developmental Dyslexia in Hong Kong Chinese Children. Clinical Practice & Epidemiology in Mental Health, 13, 104-114. doi: 10.2174/1745017901713010104. eCollection.
Chow BW, Ho CS, Wong SWL, Waye MMY, Zheng M. (2017) Home environmental influences on children’s language and reading skills in a genetically sensitive design: Are socioeconomic status and home literacy environment environmental mediators and moderators? Scandinavian Journal of Psychology, 58(6), 519-529. doi: 10.1111/sjop.12397. Epub Oct 25.
Waye MM, Cheng HY. (2017). Genetics and epigenetics of autism: A Review. Psychiatry and Clinical Neurosciences. 2017 Sep 23. doi: 10.1111/pcn.12606. [Epub ahead of print] Review.
Rao S, Leung CS, Lam MH, Wing YK, Waye MM, Tsui SK. (2017). Resequencing three candidate genes discovers seven potentially deleterious variants susceptibility to major depressive disorder and suicide attempts in Chinese. Gene, 603, 34-41. doi: 10.1016/j.gene.2016.12.006.
Liang WC, Liang PP, Wong CW, Ng TB, Huang JJ, Zhang JF, Waye MM, Fu WM. (2017) CRISPR/Cas9 Technology Targeting Fas Gene Protects Mice from Concanavalin-A Induced Fulminant Hepatic Failure. J Cell Biochem. 118(3):530-536.
Rao S, Lam MH, Yeung VS, Wing YK, Waye MM. (2016) Association of HOMER1 rs2290639 with suicide attempts in Hong Kong Chinese and the potentially functional role of this polymorphism. Springerplus. 2016 Jun 17;5(1):767. eCollection 2016.
Liang, W. C., Fu, W. M., Wong, C. W., Wang, Y., Wang, W. M., Hu, G. X., … Waye, M. M. Y. (2015). The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer. ONCOTARGET, 6(26), 22513-22525.
Rao S, Lam MH, Wing YK, Yim LC, Chu WC, Yeung VS, Waye MM. (2015) Beneficial effect of phosphatidylcholine supplementation in alleviation of hypomania and insomnia in a Chinese bipolar hypomanic boy and a possible explanation to the effect at the genetic level. Springerplus. 2015 May 20;4:235. doi: 10.1186/s40064-015-1002-y. eCollection 2015.
Liang WC, Fu WM, Wong CW, Wang Y, Wang WM, Hu GX, Zhang L, Xiao LJ, Wan DC, Zhang JF, Waye MM. (2015) The LncRNA H19 promotes epithelial to mesenchymal transition by functioning as MiRNA sponges in colorectal cancer. Oncotarget. 2015 Sep 8;6(26):22513-25
Liang WC, Wang Y, Liang PP, Pan XQ, Fu WM, Yeung VS, Lu YF, Wan DC, Tsui SK, Tsang SY, Ma WB, Zhang JF, Waye MM. (2015) MiR-25 Suppresses 3T3-L1 Adipogenesis by Directly Targeting KLF4 and C/EBPα. J Cell Biochem. 2015 Apr 29. doi: 10.1002/jcb.25214. [Epub ahead of print]
Poon MW, Tsang WH, Chan SO, Li HM, Ng HK, Waye MM (Jan 2011) Dyslexia-Associated Kiaa0319-Like Protein Interacts with Axon Guidance Receptor Nogo Receptor 1., Cellular and molecular neurobiology, 31 (1), 27-35.
Mong JL, ..., Waye MM. (Sep 2009) Associations of insulin-like growth factor binding protein-3 gene polymorphisms with IGF-I activity and lipid parameters in adolescents. International Journal of Obesity, 33(12), 1446-1453.
Sai Kam Li,... Mary M Waye (2008) Identification of key amino acids in mitochondria targeting sequence of Hepatitis B Virus X protein, Virology - http://dx.doi.org/10.1016/j.virol.2008.07.037
FRAZER Ka. et al, (2007) "A second generation human haplotype map of over 3.1 million SNPs". Nature vol.449 no.7164, pp.851-861.
SABETI Pc. et al (2007) "Genome-wide detection and characterization of positive selection in human populations". Nature vol.449 no.7164, pp.913-918.

External Service

Professional & Community Service

  • Founding President, Hong Kong Society of Behavioural and Neural Genetics (2011–present)
  • President, Hong Kong Society of Biochemistry and Molecular Biology (2006 – 2018)
  • Member, American Association for the Advancement of Science (1990 – 2014)
  • Member, American Society for Cell Biology (1990 – 2014)
  • Member, Canadian Society of Cell Biologists (1978 – 2014)
  • Lifetime Member, Cell Stress Society International (1999 – present)
  • Member, Hong Kong Association For Specific Learning Disabilities (2003 – present)
  • Member, Hong Kong Society of Medical Genetics (1992 – 2014)
  • Member, Human Genome Organization (1999 – 2014)
  • Member, Human Proteome Organization (2003 – 2014)
  • Member, International Society of Computional Biology (1997 – 2014)
  • Member, Society for the study for Endocrinology, Metabolism and Reproduction, Hong Kong (1992 – 2014)
  • Lifetime Member, Society of Chinese Bioscientists in America (1988 – present)
  • Member, Hong Kong Society of Child Neurology & Developmental Paediatrics (2005 – present)
  • Member of the Grant Panel on Engineering and Science, University of Macau (2011–2016)
  • Member of the Research Programme Sub-committee, Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, The Chinese University of Hong Kong (2004 – 2006)
  • Judge, Hong Kong Awards for Industry: Technological Achievement, HKSTP (2005 – 2006)
  • Ad hoc Reviewer, Asia-Pacific Psychiatry, Oncogene, Genomics, Genes, BioTechniques, Developmental Medicine & Child Neurology, BMC Medical Genetics, Progress in Neuro-Psychopharmacology and Biological Psychiatry and Experimental Cell Research
  • Ad hoc Reviewer for grant proposal, Wellcome Trust, UK
  • Ad hoc Reviewer for faculty employment/promotion for universities in Singapore, Taiwan, Malaysia and Macau

Editorial Service

Honourary Academic/ Clinical Appointments

  • Adjunct Professor, School of Biomedical Sciences, The Chinese University of Hong Kong (2014 – 2016)
  • Assistant Professor (cross appointment), Department of Microbiology, Faculty of Medicine, University of Toronto (1991 – 1992)